Cytoburn Reviews: Does It Work?

Cytoburn is a fat-burning supplement made by an Aurora, Colorado-based company.

By taking two capsules of Cytoburn daily, you can purportedly burn fat, control cravings, and lose weight.

Does Cytoburn live up to the hype? Or is it yet another diet pill scam? Keep reading to discover everything you need to know about Cytoburn and how it works.

What is Cytoburn?

Cytoburn is a diet pill sold exclusively online through CytoburnFat.com.

Using a blend of fiber and natural laxatives, Cytoburn can support weight loss by physically pushing waste out of your body, aiding your body’s natural elimination processes.

Cytoburn was created by a man named John Williams. John has professional medical experience and education: a 41-year old physical therapist (PT). After watching his wife gain weight and struggle to lose that weight, John created a supplement to help.

Today, anyone can take Cytoburn to suppress appetite, control cravings, and burn fat, among other benefits. The formula works by targeting a special immune system protein called cytokines, turning your cytokines into fat-burning cytokines called TSLP cytokines.

How Does Cytoburn Work?

Cytoburn contains a blend of four primary ingredients, including probiotics, natural laxatives, natural sources of fiber, and natural detoxification aids.

Together, these ingredients target cytokine cells in your immune system, turning them into “fat reducing cells”.

After the ingredients in Cytoburn enter your body, they support three main benefits:

  • Natural fat burning
  • Hunger craving control
  • Weight-loss support

Cytokines are a particular type of immune system protein. When Cytoburn activates these cells, it stimulates them to release fat from your body.

The formula is called “Cytoburn” because it targets cytokines throughout your body, turning many of these immune system cells into fat-burning cells, increasing your body’s ability to burn fat.

Other weight loss pills load your body with stimulants or contain high doses of caffeine. Cytoburn works differently. The formula includes a blend of natural sources of fiber and laxatives, among other ingredients. These ingredients aid your body’s natural weight loss processes while reducing cravings. They don’t cause instant weight loss overnight; instead, they support your diet and exercise habits to help you lose weight.

Cytoburn Ingredients

Cytoburn contains a blend of natural laxatives and natural sources of fiber. Popular in other detoxification formulas, these ingredients can aid your body’s natural elimination processes: the fiber bunches up in your digestive tract to push waste out of your body, while the natural laxatives stimulate your body to release that waste.

Cytoburn also contains a probiotic strain called Lactobacillus acidophilus to aid your digestive processes. Like other probiotics, Lactobacillus acidophilus could support your body’s good digestive processes, making it easier for you to absorb nutrients from the foods you eat, filter toxins, and pass waste out of your body.

Here are all of the ingredients in Cytoburn and how they work:

Natural Sources of Fiber (Psyllium Husk, Black Walnut Hull, Oat Bran, Flaxseed, Apple Pectin, and Glucomannan): Cytoburn contains six natural sources of fiber, including psyllium, black walnut hull, oat bran, flaxseed, apple pectin, and glucomannan. 95% of Americans don’t get their daily recommended fiber intake. That’s a problem because fiber is associated with good digestion and overall health. Adding more fiber to your diet can support healthy blood pressure, aid elimination, and make it easier to lose weight, among other benefits.

Fiber also soaks up water in your stomach, expanding the fiber to take up more physical space, which enhances feelings of fullness. Fiber makes you feel full even while passing out of your body harmlessly, which could make it easier to stick to your diet goals.

Natural Detoxification Agents (Bentonite Clay): Bentonite clay has been used for centuries for its natural detoxification properties. Studies show bentonite clay has a unique molecular structure that latches onto toxins in your body, forcing your body to expel these toxins naturally. Many people take bentonite clay supplements on their own for detoxification.

Natural Laxatives (Prune and Aloe Vera): Two of Cytoburn’s ingredients work as natural laxatives. Prune is one of nature’s best-known natural laxatives, while aloe vera has laxative properties. Studies show these ingredients can help encourage your body’s natural digestive processes. In other words, they help you poop. If you’ve felt constipated, or if you’ve struggled to release waste from your body, then taking a natural laxative could help.

Probiotics (Lactobacillus Acidophilus): Cytoburn contains a single probiotic strain called Lactobacillus acidophilus. This strain, like other probiotic strains, can help optimize digestion by supporting your body’s ability to break down foods and pass waste out of your body. Many of us have imbalanced gut microbiota, which leads to issues like bloating, indigestion, and low energy. By supporting gut bacteria with a probiotic, you can support digestion and weight gloss.

Overall, the ingredients in Cytoburn work by optimizing digestion. Good digestion is crucial for weight loss. If your gut is in suboptimal condition, you’ll struggle to lose weight.

What Are Cytokines?

Cytoburn claims to work differently than any other weight loss supplement available today: it claims to convert cytokines into a special fat-burning type of cytokine, making it easier to lose weight.

Your body has multiple types of cytokines. Cytokines are special proteins that play a crucial role in immune system activity. Your body sends cytokines throughout your body to respond to infections, illnesses, and diseases, for example.

Some cytokines are pro-inflammatory cytokines that cause inflammation, while others are anti-inflammatory cytokines that reduce inflammation. Depending on how your body reacts to disease, your body might send pro or anti-inflammatory cytokines to the area.

A 2021 study showed that a specific type of cytokine called TSLP was linked to weight loss. Researchers gave cytokines to a group of obese mice, then observed significant weight loss. The mice lost 40% of their body mass after taking this specific type of cytokine.

Although the effects were not replicated in humans, it’s possible TSLP accelerates fat burning within your body. Today, Cytoburn claims to convert your body’s natural cytokines into special fat-burning TSLP cytokines, making it easier to lose weight.

Here’s how John Williams, the physical therapist who created Cytoburn, explains the effects of the supplement:

“Cytokines are a special immune system protein, that when activated, can release fats from your body. These special immune system Cytokines are called TSLP and when activated can aid in lowering fat in your body.”

Up until 2021, cytokines were not connected to fat burning. Since the release of the 2021 study, however, researchers have found a specific type of cytokine is linked to weight loss.

How Much Weight Can You Lose?

Other diet pills dazzle you with claims of losing rapid amounts of weight in a short period of time. However, the makers of Cytoburn provide more realistic weight-loss claims.

According to the official website, you can expect to lose weight within a few months of taking Cytoburn:

“Just take 2 capsules of Cytoburn daily and you’ll notice results in a few short months.”

John Williams, the man who created Cytoburn to help his wife lose weight, claims his wife gained around 80lbs after the birth of their two children. However, it’s unclear if she lost all 80lbs after taking Cytoburn – or if she lost a fraction of that amount.

Scientific Evidence for Cytoburn

Cytoburn claims to target cytokines within your body, turning them into fat-burning molecules that accelerate weight loss. Is any of this backed by science? Can you really transform immune cells into fat-burning cells?

First, it helps to understand what cytokines are. Cytokines are small secreted proteins released by cells. They have a specific effect on the interactions and communications between cells. There’s no single “cytokine” cell; instead, there are multiple types of cytokines that affect different parts of the body. Specific types of cytokines include lymphokine (cytokines made by lymphocytes) and interleukin (cytokines made by leukocytes).

Your body has both pro-inflammatory and anti-inflammatory cytokines. Some cause inflammation, while others reduce it. When your body detects infections or diseases, for example, it sends cytokines to the area. Chemotherapy, for example, involves manipulating cytokines (called chemokines) to move towards a target.

For decades, there was limited evidence connecting cytokines to weight loss. In 2021, however, researchers at the Perelman School of Medicine at the University of Pennsylvania unexpectedly found cytokines led to a significant reduction in abdominal fat and weight loss.

Researchers treated obese mice with the cytokine known as TSLP, which led to a significant reduction in abdominal fat and weight loss compared to a placebo. Researchers described it as a “completely unforeseen finding,” but found thymic stromal lymphopoietin (TSLP), a type of cytokine involved in immune system activity, helped obese mice “shed 40 percent of their body weight by secreting fat through their skin.”

However, it’s unclear how Cytoburn impacts cytokines in your body, activates TSLP, or raises TSLP activity within your body, among other effects. Instead, the formula mostly contains a blend of natural laxatives and natural fibers. These ingredients are linked to weight loss, but they’ve not been proven to activate TSLP.

In this 2019 study, researchers found a specific connection between fiber intake and weight loss in a group of overweight adults. Researchers told adults to follow a calorie-restricted diet. Some adults took more fiber than others. Adults in the fiber group were better able to stick to the low-calorie diet, and they lost more weight.

Cytoburn also contains natural laxatives like prunes and aloe vera extract. Prunes are one of nature’s best-known laxatives, and science backs up that claim. In this 2014 study from the University of Liverpool, for example, researchers found eating dried prune fruit was associated with significantly more weight loss than a placebo. Researchers found eating prune enhanced feelings of fullness, making it easier to stick to a diet plan.

Overall, Cytoburn contains a collection of ingredients that should help you feel fuller, making it easier to stick to your calorie-restricted diet. If you’re struggling with weight loss because of poor dietary habits, or if you need extra help, then Cytoburn may be able to suppress appetite and encourage weight loss. However, there’s limited scientific evidence proving it changes your immune system’s general cytokines into fat-burning TSLP cytokines.

Cytoburn Ingredients Label

The makers of Cytoburn disclose their full list of ingredients upfront. All ingredients are packaged into a proprietary formula. Individual dosages are hidden, although we know all of the ingredients.


Here’s what you get with every two capsules serving of Cytoburn:

  • 1.5g of a proprietary blend with psyllium husk, bentonite clay, black walnut hull, oat bran, flaxseed, prune, aloe vera leaf, Lactobacillus acidophilus, apple pectin, and glucomannan
  • Other (inactive) ingredients, including gelatin, magnesium stearate, and silicon dioxide

Cytoburn Pricing

Cytoburn is priced at $69 per bottle, although the price drops as low as $39 per bottle when ordering multiple units.

Here’s how pricing breaks down when ordering online today:

  • 1 Bottle: $69 + Free US Shipping
  • 3 Bottles: $177 + Free US Shipping
  • 6 Bottles: $294 + Free US Shipping

Each bottle contains a 30 day supply of Cytoburn or 60 capsules. You take two capsules daily to lose weight.


Cytoburn Refund Policy

Cytoburn is backed by a 60-day risk-free moneyback guarantee.

If you are unhappy with the results of Cytoburn for any reason, then you can request a complete refund within 60 days of your purchase.

About Cytoburn

Cytoburn is manufactured in the United States at an FDA-registered, GMP-certified facility. The formula was created by a 41-year old physical therapist (PT) from Florida named John Williams.

John was motivated to create Cytoburn after watching his wife, Sarah, gain 78lbs after giving birth to their two children. Sarah struggled to lose weight with conventional diet and exercise strategies, but she lost weight with Cytoburn.

You can contact the makers of Cytoburn via the following:

  • Email: support@renewproducts.zendesk.com
  • Mailing Address: 19655 E 35th Dr, #100, Aurora, CO 80011, USA
  • Phone: 858-461-6727

Final Word

Cytoburn is a weight loss supplement that targets special immune system cells called cytokines, turning them into fat-burning cells for maximum weight loss.

By taking two capsules of Cytoburn daily, you can purportedly suppress appetite, burn fat, and lose weight – all while using natural fibers and laxatives instead of dangerous stimulants.

To learn more about Cytoburn and how it works, or to buy the supplement online today, visit the official website at CytoburnFat.com.