Review the Top 5 Best Adderall Alternative Supplements of 2021

Of all the neurological disorders that are diagnosed during childhood, one that has had a significant influence is attention deficit...

Of all the neurological disorders that are diagnosed during childhood, one that has had a significant influence is attention deficit hyperactivity disorder (ADHD). Matter-of-factly, in the U.S. alone, the number easily surpasses one million children. For people who aren’t entirely aware of ADHD, it is a condition whereby consumers experience a lack of focus and are often distracted. The general belief is that the neural pathways fail to achieve complete connection in such individuals at the same rate as a normally functioning brain. This leaves them feeling overwhelmed even by regular tasks.

Medication is one of a handful of ways that ADHD is treated, one of them being, Adderall. However, with such approaches, side effects need to be forestalled. Adderall has been linked to poor sleep quality, suppressed appetite, prolonged development, headaches, stomachaches, moodiness, and irritability [1]. Children strictly experience the latter consequences. Undoubtedly, following a health practitioner’s advice is always recommended. However, is there any harm if additional, all-natural supplements are also included in one’s routine? Natural supplements do not cure or treat diseases under any circumstances, but they drive results to some degree.

Following those mentioned above, our editorial team was curious whether the supplements market carries solutions that target symptoms linked to ADHD. After further investigation, we discovered seven that underwent thorough analyses. The following guide will reveal what our picks are and provide education surrounding the entirety of ADHD.

The Top 5 Adderall Supplements of 2021

The process by which the seven supplements have been selected is quite extensive. Henceforward, we will first introduce them and later explain what indeed drew us to them.

  • Mind Lab Pro
  • Modafinil
  • NooCube Brain Productivity
  • Performance Lab Mind
  • SANE Vitaae

Listed below is a brief overview of the makers, formula, and credible benefits for each one:

Mind Lab Pro v4.0

  • Company: Opti-Nutra Ltd.
  • Starting Price: $69

Opti-Nutra Ltd is back at it again with the fourth version of its nootropic supplement called Mind Lab Pro. This formula has been advanced to serve as a whole-brain optimizer that promotes peak mental performance. Earlier, we noted that ADHD’s most significant symptom is the lack of focus. Well, this supplement is trusted to reverse such issues and poor productivity, mood, and energy. That said, several facets help Mind Lab Pro v4.0 to stand out from the crowd.

Its formula is said to tap into 5 to 6 different brain pathways essential for ideal performance for starters. Second, it has been subjected to double-blind, placebo-controlled trials, which Leeds University, United Kingdom, independently conducted. Lead researcher, Dr. Andrea Utley BA, was quoted saying, “I was surprised by the degree of statistical significance,” adding that processes for publication are currently underway. If this isn’t enough, Mind Lab Pro has sold millions of bottles to date! This solution is sought for focus, clarity, memory, mood, and long-range brain health regarding benefits.

On the topic of formula, we have the serving per day (i.e., 2 to 4 capsules), which encompasses the likes of Vitamin B6 (2.5mg), Vitamin B9 (100mcg), Vitamin B12 (7.5mcg), Citicoline (250mg), Bacopa Monnieri (150mg), Organic Lion’s Mane Mushroom Fruit (500mg), Sharp-PS (100mg), N-Acetyl L-Tyrosine (175mg), L-Theanine (100mg), Rhodiola Rosea (50mg) and Maritime Pine Bark Extract (75mg). This formula kicks things up a notch in just 30 minutes.


  • Starting Price: $10/capsule

There’s something we want to be honest with all readers about. Technically, our research didn’t lead us to seven all-natural supplements. It led us to six. Modafinil, also known by the brand-name, Provigil, is a prescription medication used to prevent individuals from falling asleep during the day. In other words, one can expect to get into a regular sleep routine. Some of the most common health concerns that Modafinil is recommended for include obstructive sleep apnea, narcolepsy, and sleep disorders. However, side effects are unavoidable and might range from headaches, nausea, and nervousness to dizziness and possibly severe allergic reactions and chest pain [2]. Bearing everything in mind, we feel everyone should consult a health professional before adding this medicine to their routine.

NooCube Brain Productivity

  • Company: Wolfson Brands (UK) Limited
  • Starting Price: $59.99

NooCube Brain Productivity combines natural nootropics to help support and enhance focus, mental speed, and memory. Wolfson Brands (UK) Limited is the supplier and manufacturer of this supplement, which appears to have been formulated by S.O. Labs. We gathered that the makers take pride in offering 100% effective ingredients based on well-researched formulas from our research. The team of nutritional experts, fitness professionals, and health consultants agree that vitamins, amino acids, and other essential building blocks support optimal mental performance.

Just like Mind Lab Pro v4.0, NooCube also elicits initial results within 30 minutes and may last approximately 8 to 10 hours. We know that each serving (i.e., two capsules) embodies the coming together of Alpha GPC, Cat’s Claw, Oat Straw, Huperzine A, Bacopa Monnieri, L-Theanine, L-Tyrosine, Pterostilbene, and Resveratrol. One thing that we weren’t as excited by was the lack of clarity on concentration per dose. Hence, we encourage everyone to contact the Wolfson Brands (UK) Limited or S.O. Labs teams regarding the supplement’s fact before proceeding.


  • Company: Performance Lab
  • Starting Price: $89

Mind is broadcasted as an Ultramodern nootropic that may promote brain power, brain health and prevent individuals from undergoing burnouts. When taken as directed, one’s focus, memory, and speed are assumed to reach all new heights. Speaking of Ultramodern Nutrition, this consists of a series of curated nutrition technologies that Performance Lab typically focuses on to ensure that clinical research as a factor is met. This is of no surprise to us, as the company has since earned the title of “the world’s most sophisticated nutritional supplement system for optimizing daily performance and long-range health.” Concerning the Mind formula, which is the simplest of the bunch so far, each NutriCap (i.e., solely vegetarian capsule without unnecessary ingredients) delivers a decent amount of Cognizin (250mg), Sharp-PS (100mg), L-Tyrosine (250mg), and Maritime Pine Bark Extract (75mg).


  • Company: SANE Laboratories
  • Starting Price: $47

Vitaae is an anti-aging clinical research formulation believed to reverse symptoms associated with leaky brain syndrome. Leaky brain syndrome occurs when the brain’s protective layer of cells, i.e., compromised blood-brain barrier. The loosening or breaking of junctions leads the brain to encounter harmful substances [3]. So, what symptoms does Vitaae intend to eliminate? The team at SANE Laboratories is convinced that their formula can gradually ease low energy, prolonged metabolism, memory loss, lack of focus, anxiety, depression, and possibly mood swings.

Founded in 2014, SANE Laboratories is yet another company driven by the latest research to ensure that consumer wellness is protected at all costs. All their products have undergone thorough testing and were manufactured in the U.S., in an FDA-approved facility. What drew us to this company is their level of recognition – to the point where they are listed on Inc. 500’s list of America’s Fastest-Growing Private Companies. In addition, they provide free nutritional guides that further enhance brain function.

Finally, in terms of the formula itself, each serving (i.e., three capsules) contains Vitamin D (125mcg), Magnafolate C (667mcg), a 1800mg-proprietary blend of Acetyl L-Carnitine HCL, L-Carnitine Tartrate, Gymnema Sylvestre, and Omega-3, Citocoline (100mg) and Coenzyme Q-10 (50mg).

A Complete Breakdown of Our Ranking System

As much as we’d love to believe every inch of detail found online, the mounting evidence of scammers prevents us from doing so. Therefore, our entire editorial team sat down to devise a ranking system by which products would be chosen. To keep things simple, we selected factors that everyone agreed on. After some hundred supplements, only seven checked off multiple, which to us was comforting. Of course, this system can be adjusted to one’s liking, as there is no one approach to narrow down options. And so, we were content with the following:


Transparency is usually overlooked but, sensibly, it is factored into everything. Whether it be company background, precise information on the supplement’s fact and bottle labeling, a breakdown of methodologies, etc., the moment individuals are deprived of the knowledge that involves their health, solutions should be immediately ignored.

Company Background/Manufacturer Repute

Recently, some supplements have been making their way into the market despite evidence of lack of company background and manufacturer reputation. This factor aligns beautifully with transparency, as the lack of knowledge leads to heightened doubt and frustration. In general, we shouldn’t be supporting a supplement company that doesn’t proudly own up to their supposed formulas.

Scientifically Backed Ingredients and Dosing

ADHD symptoms can be alleviated with medication and treatment. However, it still is no small feat to live with. Thus, if we insist that our top picks can serve as an alternative or, more realistically, add to existing treatments, we want some scientific assurance for effectiveness. Our goal was to refrain from solutions that touted traditional treatments only because the evidence on certain types isn’t as strong. Another feature that we were hoping for was Generally Recognized As Safe (GRAS)-labeled ingredients, which the FDA has say in.

Realistic Advertised Benefits

Dietary supplements by no means cure diseases. We mentioned this earlier in this piece and will continue to reiterate it because of its significance. On that note, some companies tend to exaggerate results, and our editorial team highly frowned upon this deceptive approach of luring customers. So, if we stumbled upon any outlandish claims, we ignored the solutions entirely.

Additional Supporting Incentives

There have been instances where companies approached nootropics similarly. There were some during our search that carried identical ingredients but at slightly different concentrations. How do we choose between the two? Well, first, we need to make sure that the doses fall within the proven ranges. If both satisfy this requirement, then our go-to was to see whether they possessed any competitive advantages. These could be in the form of money-back guarantees, clinical trials, medical or scientific advisory boards, positive customer feedback, etc. Additional supporting incentives symbolize a company’s efforts and commitment to supporting consumer safety and wellness.

Value for Price

Finally, we have value for the price. The more factors that a supplement checks off from our list, the more valuable it is. In what way would a supplement lacking substance surpass another one that abides by regulations, considered clinical trials, and has taken the extra step to educate consumers? It probably won’t. The idea that a higher-priced product is superior has long faded, and we hope that individuals will learn to ignore price until the very end. Otherwise, the value of a product cannot be determined.

The Scientific Account: Do Adderall Alternatives Have A Chance?

The first-ever Adderall was launched and approved by the FDA in 1996. Since then, a second version called Adderall XR was introduced in 2001 as a quick-release tablet. That said, this remains a top contender as a prescription medication even after 25 years, so we need to ensure that our top picks do carry evidence for effectiveness. But before jumping to the science of natural ingredients, we must understand the mechanism of Adderall.

The Sneak Peek Into How Adderall Works

According to Healthline, Adderall works by stimulating the central nervous system. Specifically, it has been designed to increase the availability of norepinephrine and dopamine neurotransmitters, which will fasten our brain activity. Like Adderall, there also exists Ritalin, i.e., a solution that can speed up the process of attaining peak performance, but the results are long-lasting with the former than the latter. The choice between the two supposedly depends on one’s individual needs and preferences [4].

Getting back to our discussion on all-natural alternatives, we decided it’s best to stick to the top five recurring ingredients across most of the supplements of 2021. Now, this has been done to depict the process of elimination. When the time to place an order arrives, individuals are asked to review the entire ingredient list and consult a health practitioner before proceeding. Anyways, let’s get started:


Researchers of one study that looked at the effects of a citicoline-caffeine-based beverage in 60 healthy adult participants enrolled in a randomized, double-blind, placebo-controlled trial claim to have found statistical significance. Precisely, they found that 250mg was appropriate to see improvements in attention and working memory. That said, they did report some limitations of the study, i.e., including younger adults, as studies with older adults can only be generalized to the aging population [5]. One source that summarized studies on alternative approaches to easing ADHD symptoms referenced a 2014 review in saying that “citicoline supplements may help with brain and nervous system disorders like glaucoma and certain kinds of dementia. It may also help to reduce symptoms of ADHD [6].”


Sharp-PS is a high-quality, patented, and clinically proven form of phosphatidylserine, i.e., a type of lipid that serves as building blocks of cell membranes. This respective ingredient is supposedly much more concentrated in neuronal tissues and the brain than other tissues. As for scientific evidence, its ingestion has been shown to increase neurotransmitter secretion in the brain, improve neuron survival, and induce learning and the formation of memories. Other benefits include supporting sharp thinking, concentration, cognitive skills – which have been noticed from children and students to the elderlies [7].

Alpha GPC

L-Alpha glyceryl phosphorylcholine (Alpha GPC) is a naturally found choline in the brain. It turns out that this ingredient is needed to stimulate levels of a neurotransmitter called acetylcholine, which is essential for memory and learning. A 2015 study looked at 200mg of Alpha GPC, caffeine, or placebo on mood, cognitive function, and physiological performance effects. Though caffeine seemed to prevail in most areas, Alpha GPC was reported to “be beneficial for certain physical and mental performance tasks [8].” A more recent source explained that preclinical studies were the most successful at seeing results. Consequently, this ingredient requires further investigation [9].

Bacopa Monnieri

Bacopa monnieri is an herb popularly used in Ayurveda as a means of improving cognitive function. That said, one study that assessed the effect of two doses: 300mg and 600mg, on healthy elderly participants, reported that after 12 weeks of ingestion, factors including attention, processing information, and memory were improved. Once again, it would have been nice to see whether similar results could be garnered if we diversified the sample to include younger adults [10]. A more recent study with similar intentions arrived at inconclusive results. If anything, the effects were reversed, i.e., showing that the control group prevailed. We found a low sample size, which might/might not explain insignificance [11].

Huperzine A

Huperzine A is typically found in the brain and cognitive enhancing supplements because it is trusted to improve neurotransmitter concentrations in the brain. Our search led us to a rat-based model that managed to show that ingesting this ingredient may improve cognitive dysfunction while minimizing the damaging influence of free radicals [12]. To understand its mechanism, one source noted that it works by activating the cholinergic system (i.e., which implies better perceptual learning) and triggering the acetylcholine neurotransmitter critical for attention and memory [13].

Frequently Asked Questions About Adderall

Q: What is ADHD?

A: ADHD is a neurological disorder where the brain faces struggles with development. This condition is often diagnosed in childhood and will persist well into adulthood [1].

Q: What are the signs and symptoms of ADHD?

A: To identify and diagnose the condition in one’s childhood, parents are often asked to see whether their child is lost in their own world, is forgetful, squirms or fidgets a lot, talks a lot, has difficulty resisting temptation and making friends, and cannot focus [1].

Q: How many types of ADHD are there?

A: There are three types of ADHD, which include predominantly inattentive presentation, predominantly hyperactive-impulsive presentation, and combined presentation. In the first case, individuals struggle to finish a task, get easily distracted, or are forgetful. In the second case, it seems almost impossible to keep them in their seats. In children, this includes running, jumping, and climbing. Individuals who have this are also talkative and tend to interrupt others unknowingly. In the last case, individuals experience a bit of both [1].

Q: What are possible risk factors for ADHD?

A: As per the recent update provided by CDC, possible risk factors for ADHD include brain injury, exposure to harmful substances, alcohol and tobacco use during pregnancy, low birth weight, and premature delivery [1].

Q: What is the scientific explanation for ADHD?

A: It turns out that deficiencies in a neurotransmitter called norepinephrine are the leading cause of ADHD. Given that it works alongside our reward and pleasure system, i.e., dopamine, the absence of the former leads to limited activities in the frontal cortex (i.e., attention, executive function, organization), limbic system (i.e., regulates emotions and attention), basal ganglia (i.e., leading to inattention and impulsivity), and reticular activating system (i.e., leading to inattention, impulsivity, or hyperactivity) [14].

Q: Is there a single test to diagnose ADHD?

A: There is no single test to diagnose ADHD, as it includes other concerns such as anxiety, depression, sleep problems, and specific learning disabilities. Typically, a doctor requires a medical examination that considers hearing and vision tests to ensure those occurring symptoms aren’t confused for ADHD [1].

Q: What are some treatment options for ADHD?

A: The best treatment options for ADHD include a combination of behavior therapy and medication. Younger children are started with behavior therapy before proceeding to drugs [1].

Q: Can making appropriate lifestyle choices help ease symptoms of ADHD?

A: CDC encourages parents of children with ADHD or adults with ADHD to eat a balanced diet, ensure participation in physical activity, decrease screen time on electronics, and ensure quality sleep is attained [1].

Q: What is Adderall?

A: Adderall is a prescription medication that combines a specific ratio of dextroamphetamine and amphetamine to treat ADHD or narcolepsy (i.e., daytime sleeping) [15].

Q: How does Adderall work?

A: It has been formulated to alter specific naturally occurring chemicals in our brain to induce the effects of critical neurotransmitters, two of them being dopamine and norepinephrine. For people with ADHD, Adderall can improve hyperactivity, impulsivity, and attention span [15].

Q: Has The FDA approved Adderall?

A: Yes, the first-ever Adderall was approved by the FDA in 1996.

Q: Is Adderall the only prescription medication?

A: Adderall is just one of a handful of brands that supports people with ADHD. Others include Dexedrine (includes dextroamphetamine), Zenzedi (includes dextroamphetamine), Focalin (includes Dexmethylphenidate) and Methylin and Ritalin (includes Methylphenidate) [16].

Q: Can someone without ADHD take Adderall?

A: Yes, it will have the same effect on a normally functioning brain as on an ADHD brain. That said, there are mental function-related side effects, all of which should be weighed before considering such an action [17].

Q: How do you know that Adderall has finally kicked in?

A: The right dose will boost focus, have better control over one’s emotions, and may alleviate hyperactivity. If individuals can think clearly, complete assigned tasks, and are rarely distracted, whether during a task or while conversing, these are signs that Adderall has kicked in [18].

Q: How long will Adderall last?

A: Adderall is believed to last anywhere between four and six hours [16].

Q: Will Adderall create dependencies?

A: Yes, people who take Adderall are at risk of becoming physically dependent on prescription medication. This drug is easily tolerable and may push individuals to take higher doses against a doctor’s advice [19].

Q: Are there any signs of Adderall addiction?

A: According to the American Addiction Centers’ Oxford Treatment Center, the following signs indicate that people may be suffering from stimulant use disorder [19]:

  • Clinically distressed or impaired in different areas of functioning
  • Displaying lack of control when taking Adderall
  • Continued use of Adderall at significantly high doses
  • One or more physical dependence is witnessed

Q: What is a nootropic, and why might it help someone with ADHD?

A: A nootropic is a dietary supplement that naturally induces stimulant effects for optimal brain performance and cognitive skills. It is the general belief that people with ADHD can benefit from the addition of a nootropic because they are deficient in certain cognitive functions (i.e., attention, concentration, productivity, etc.)

Q: How do Adderall and nootropics differ?

A: For starters, Adderall has been approved by the FDA, while nootropics are not. Second, a prescription is needed for Adderall, whereas nootropics can be purchased online or over the counter. Adderall contains stimulants, whereas most nootropics contain vitamins, minerals, plants, and herbs.

Q: Is it better to stick to nootropics rather than Adderall?

A: This is often asked, and unfortunately, there is no straight answer here. It is best to have this discussion with a health practitioner who knows one’s medical history. That said, it is rare that a nootropic would be recommended over Adderall. Hence, individuals should do their respective research to limit medication interactions and possible compromises to their health.

Q: What are ideal alternatives for Adderall?

A: A good first step would be to refer to our top 5 dietary supplements above. Others with similar features would also suffice as ideal alternatives for Adderall.

Q: How does Adderall affect depression and anxiety?

A: A high dose of Adderall could induce feelings of sadness or other lethargic behaviors linked to depression. Similarly, the belief that Adderall can help with anxiety is nothing but a myth. High doses may worsen one’s anxiety [20].

Q: Is Adderall safe for both children and Adderall?

A: When a proper dose is prescribed, it can be safe for both children and adults. Therefore, a prescription is needed.

Q: What are the common side effects of Adderall?

A: Side effects include circulatory issues, increased blood pressure and heart rate, anxiousness, difficulty sleeping, back pain, and flu-like symptoms, to name a few. It is seldom recommended over the long run; therefore, most symptoms can be defeated with time. It is important to note that people with a normally functioning brain who plan to take Adderall will have to live with long-term effects, some of which include anxiety, euphoria, paranoia, hallucination, and psychosis. These are deemed results that stem from an excess of neurotransmitters found in the brain [20].

Q: Is Adderall safe during pregnancy?

A: It depends mainly on medical histories; thus, a health professional’s opinion should be sought.

The Top 5 Adderall Supplements of 2021 Final Verdict

Ultimately, natural alternatives to Adderall and other related prescription drugs are gradually making their way into society. Whether they are a complete match is questionable, as more research is needed on the effects of nootropics as a whole on the brain. Nevertheless, our editorial team is convinced that adding the likes of vitamins, minerals, antioxidants, herbs, plants, building blocks, you name it, can be beneficial as long as there aren’t any medication interactions. Although nootropics do not require prescriptions, it won’t hurt to sit down with a health practitioner to understand its mechanism, how it might influence one’s respective health (considering unique factors), and whether it is, in fact, necessary. Adderall is usually recommended for kids and over the short run, so transitioning into natural ways of boosting cognitive function might be a viable option when they reach adulthood.

We hope that we successfully listed our top picks for 2021 and provided clear arguments on why they have been selected, i.e., the ranking system, scientific evidence, and an FAQ section. The average consumer tends to determine the worth of a solution based on reviews and price, but in reality, there’s more to it, and what we provide here is just a foundation. We want to encourage everyone to take the extra mile to educate themselves, as anything involving dietary supplements implies positive or negative impacts on our health. We trust that this guide may have provided some assistance on where and how to get started.

ALSO READ: Noom Reviews: Does It Work? Is It Legit? Worth the Money to Buy?

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Please understand that any advice or guidelines revealed here are not even remotely a substitute for sound medical advice from a licensed healthcare provider. Make sure to consult with a professional physician before making any purchasing decision if you use medications or have concerns following the review details shared above. Individual results may vary as the statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease.