Are you able to freely lift your arm away from your body? If yes, can you now reach for your head then to your toes? These are just a fraction of the movements facilitated by our joints. Joints are critical to our musculoskeletal system, as they, alongside bones and muscle, permit humans to partake in physical activities of all kinds. When consumers fail to take heed to any discomforts or pain, they are setting themselves up for a series of joints’ related conditions, yielding limited independence.
How can we resolve joint discomforts or pain? Although society continues to advocate ongoing movement and healthy lifestyle choices, there’s no harm to have added support intended to drive beneficial outcomes. Such care can be attained in the form of dietary supplements, and this is where our editorial team enters the scene. At present, the 2026 estimate for bone and joint health is roughly $41,458.9 million , which could only mean one thing: there are and will be plenty of solutions out there!
So, we decided to take charge of this situation and delved into the market. After reviewing several interest factors (which will be covered later in this piece), a consensus was reached on 32 supplements. These, we can say to some degree, are reckoned as the top-performing joint supplements of 2021. Interested to find out more? Let’s get cracking with this guide.
- Performance Lab Flex
- Joint Care
- Icelandic Pure
- Advanced Joint Support
- Joint 33X
- CBD Infused Cream
- Maximum Flex
- Ultimate Pain Balm
- Super Joint Support
- Instaflex Advanced
- Jocko Joint Warfare
- Pain Relief Cream
- Move Free Advanced
- Nature Heals Proflexoral
- Triple Joint Health
- Ultra Joint Relief Pro
- Joint Pain Hack
- Joint Support +
- Joint Oil
- Move Joint Health Formula
- Joint Relief 911
- ProJoint Plus
- JointRestore Gummies
- Joint Support
- Joint Guard 360
- Golden Revive +
- Glucosamine Chondroitin Turmeric & MSM
- Joint N-11
- Longevity Activator
The Top 32 Performing Joints Supplements in 2021
To acquaint everyone with the qualifying joint supplements of the year, our editorial team felt it was necessary to provide a synopsis of the supplement and its contents, introduce the maker’s (if applicable), and report the listed benefits. In a randomized order, here’s everything requiring reflection moving forward:
- Company: Performance Lab
- Starting Price: $89.00
Flex is a dietary supplement intended to promote joint lubrication and shock absorption, support ligaments, tendons, and cartilage, and possibly alleviate stiff and achy joints. Created by Performance Lab, the thought process for this solution involves delivering joint nutrients, most of which stem from patented ingredients.
At Performance Lab, the goal is to develop a sophisticated supplement system destined for daily performance and long-range health. This led the team to conceptualize and execute advanced nutritional technologies and lab-grown, ultramodern nutrition (i.e., NutriGenesis). Then, there are NutriCaps softgels, which are 100% vegan and the first of their kind made using tapioca, glycerin, and purified water only.
By taking each serving (i.e., 2 Nutricaps) as recommended, individuals can anticipate peak flexibility, resilience, and comfort regardless of the demanding nature of physical activities. On the topic of serving sizes, each one reflects the togetherness of CurcuWIN Turmeric (250mg), AprèsFlex Boswellia serrata (100mg), Glucosamine Sulfate (500mg), Mythocondro (100mg), OptiMSM (100mg), and NutriGenesis Strontium+ (300mcg).
- Company: Vital Plan
- Starting Price: $49
Researched and developed by Dr. Bill Rawls, the Joint Care formula has been designed to support healthy joint function while promoting activeness. Over time, individuals can anticipate improved flexibility, healthy inflammatory response, and cartilage function. Speaking of Dr. Bill Rawls, his passion for the herbal approach to wellness didn’t flourish until he faced an undiagnosed medical condition. Failing to find the right cure, his path crossed with that of herbs, and after some ten years, he became a modern herbologist known for targeting the root causes of several diseases.
Vital Plan is B-Corporation-certified (i.e., given to companies that meet the highest standards of social and environmental performance, accountability, and transparency), are following the need for extra testing and ensure that each botanical comes to its appropriate ID. Each serving (i.e., three capsules) is said to be equipped with the likes of Acumin Turmeric (250mg), NEM Eggshell Membrane (250mg), Bromelain (225mg), Boswellia Extract (100mg), and Hyaluronic acid (80mg).
- Company: Leading Edge Health
- Starting Price: $49.95
By its looks, Icelandic Pure goes beyond easing joint health thanks to the inclusion of collagen. In other words, individuals can forestall healthy skin, joints, and gut functions. The secret rests in collagen, sourced from the wild-caught, deep-sea Icelandic Cod, per the claims made. This choice of fish has been supported by its ability to absorb 1.5 times better than collagen derived from any other source.
Leading Edge Health has been around for the longest (i.e., since 1999) of all the companies listed in our guide. It has been operating with the goal of “providing anti-aging, skincare, and health products designed to make you feel more youthful, attractive and vibrant.” From the involvement of medical professionals and significant retailers right down to the money-back guarantee, this company and its solutions have been well-received by consumers. Each serving (i.e., six capsules) is said to encompass a whopping 2700mg of Pure Hydrolyzed Marine Collagen from GenF20.
Advanced Joint Support
- Company: Advanced Bionutritionals
- Starting Price: $69.95
Advanced Joint Support is a 7-in-1 supplement that has been designed with joint flexibility and health in mind. According to the Advanced Bionutritionals team, 5-Loxin is the best ingredient out there, as the patented Boswellia (along with supporting components) is believed to promote relief on a whole new level. Our general opinion regarding Advanced Bionutritionals is positive primarily because the team encompasses health experts with decades of experience.
Aside from the involvement of doctors, naturopaths, and acupuncturists, their nine principles of quality were uplifting. Some of which entails establishing healthy, long-term relationships with suppliers and growers, relying on scientifically backed ingredients, eliminating artificial and non-GMO ingredients, ensuring that parties within the supply chain do qualify, and encouraging batch-by-batch analyses.
On that note, each serving (i.e., four tablets), comprised of Calcium (1500mg), 5-LOXIN Boswellia (200mg), White Willow (480mg), Meriva Turmeric (200mg), Mojave Yucca (200mg), Q-actin Cucumber (20mg), and Boron (5.4mg).
- Company: BioTRUST
- Starting Price: $49
Joint 33X is a 3-in-1 supplement that promotes healthy joints, increased flexibility, and function. The team at BioTRUST insists that there are three common factors related to aging, which gives rise to poor joint health. These include a decline in collagen (i.e., a protein that increases cushioning between joints and bones), hyaluronic acid (i.e., or joint fluid), and excess levels of enzymes (i.e., which can have a reverse effect on collagen production). Thus, the Joint 33X formula can be perceived as a solution that remedies those above three.
Joel Marion and Josh Bezoni envisioned BioTRUST as a premier online nutrition brand promoting wellness and giving back to the community. After the first year into business, the duo watched their company skyrocket with over one million products sold. What drew consumers to this brand? Reasons may range from their choice for sustainably sourced ingredients and “NO JUNK Policy” to upkeep industry-level quality control, providing educational material, and working with top-tier manufacturers.
Finally, the ingredients, where the recommended serving size (i.e., one capsule) is said to include AprèsFlex Boswellia serrata (100mg), Mobilee Standardized Rooster Cartilage Extract (40mg), and UC-II Standardized Chicken Cartilage Extract (40mg).
CBD Infused Cream
- Company: CBDPure
- Starting Price: $40
Diverging from supplements for a second is a topical solution called CBD Infused Cream brought to us by CBDPure. The purpose of this cream is to soothe aches and pains by targeting the precise pain source and increasing a healthy range of motion. The biggest takeaway here is the inclusion of cannabidiol (CBD), which has been liked for its anti-inflammatory effects on the entire body.
Regarding CBDPure, the company pledges to be cruelty-free while equally prioritizing leading-edge research, clean and potent ingredients, and quality control. Individuals can access the certificate of analysis for the CBD Infused Cream, which confirms the inclusion of CBD and small traces of CBC and THC. The CBDPure team went beyond CBD to further enhance results and considered a handful of others, including Menthol, Jojoba Seed Oil, Polyacrylamide, Squalane, Eucalyptus Globulus Leaf Oil, Apricot Kernel Oil, Sodium Hyaluronate, and Salix Alba Bark Extra, among others.
- Company: CellGrail
- Starting Price: $49.99
Maximum Flex is a joint health supplement that aims to reduce stiffness, promote cartilage production, and increase comfort and flexibility. As explained by the CellGrail team, long-term all-natural solutions help alleviate symptoms linked to a series of joint-related conditions. After delving into the scientific approach to healing, the group claims to have had their hearts set on eight primary ingredients found in every three capsules. These include Glucosamine Sulfate (1500mg), Boswellia Extract (200mg), Chondroitin Sulfate (150mg), Turmeric (150mg), Quercetin (25mg), Methionine (25mg), MSM (25mg) and Bromelain (25mg).
Getting back on the topic of makers, CellGrail allegedly entered the supplements industry because the creators wanted to spread one message, i.e., “Give your body time to heal!” The need to facilitate healing and keep consumers on track led them to create an array of solutions to target the root cause of some of the most common chronic diseases.
Ultimate Pain Balm
- Company: Cymbiotika
- Starting Price: $56
Another topical solution that qualified for this guide is the Ultimate Pain Balm, which, as described, combines plant compounds and stem cells to soothe aches and pain. Penetrating deep within the layers of our skin, individuals can anticipate relief and feelings of warmth suggesting muscular healing. How can anyone abandon its inflammation-reducing potential?
That said, Cymbiotika is no stranger to the supplements industry, as their solutions represent the combined experiences of scientists and doctors, maximum bioavailability, and the purest ingredients. Then there’s their commitment to excluding anything from chemicals and animal products to common allergens. Nevertheless, this formula is trusted to achieve results mainly by increasing blood flow and circulation – ensuring a speedy recovery.
Finally, we have ingredients which entail Organic MCT Oil, Beeswax, Menthol, White Camphor, Argania Stem Cells, Pineapple Enzymes and Peppermint, Spearmint, Cinnamon, Arnica, Turmeric, Calendula, Vitamin E, Blue Tansy, Lavender, Ginger, Grape Seed, Eucalyptus, Meadowfoam Seed, and Argan oils.
- Company: N/A
- Starting Price: $69
Up next, there’s Flexotone, a solution touted for its joint healing characteristics. Unfortunately, our editorial team was skeptical about its uses despite the demand for it. A presentation for this supplement bashes big pharma, arguing that their intentions are ill and are unlikely to provide relief. Conceptualized and brought to the market by a supposed Dr. Ernest Pramza, whose credentials were not verifiable, Flexotone “can completely rid you from the debilitating nightmare of joint pain.” The latter is possible because the formula targets nociceptive pain (i.e., the nerves) triggered by a particular bacterium.
Concerning the Flexotone formula, we know that 18 plant extracts were chosen, including (but not limited to) Thiamine, Riboflavin, Niacin, Folate, Euterpe Oleracea, Vitamins B6, B7 and B12, Magnesium, Pantothenic Acid, L-Taurine, Spirulina algae, Eurycoma, Ginseng, and Maca. Ultimately, the lack of company background, an unverifiable creator, and a non-existing supplement’s fact outweigh any potential benefit. These are what prevented us from seeing its supposed worth.
Super Joint Support
- Company: The Healthy Back Institute
- Starting Price: $69.95
Super Joint Support is comprehensive joint support that provides the body with bone-building nutrients. Captivatingly, the Healthy Back Institute’s makers affirm to have created this formula with three essential steps in mind. First, it searches for the source of discomfort and reduces irritation. Second, it delivers critical nutrients for enhanced cartilage production. The final stage is where the rebuilding and strengthening of bones take place. The embedded ingredients are reckoned to “promote [the] removal of old bones that has been damaged by years of joints grinding together and from disintegrating cartilage.”
As a company, The Healthy Back Institute took shape to help people with back pain issues. Soon after, they broadened their business plan to cover any kind of muscle, joints, or nerve pain condition. Today, they are on a mission to “help [everyone] live the pain-free life [they] deserve without resorting to costly and dangerous surgeries.” Founded by Jesse Cannone, CFT, CPRS, MFT, and Steve Hefferon, CMT, PTA, this company celebrates decades of hands-on experience and extensive research, which is reassuring!
Regarding ingredients, each serving (i.e., 4 capsules) contains Vitamin D (950IU), Vitamin K (45mcg), Vitamin B12 (250mcg), Magnesium (400mg), Sodium (10mg), Glucosamine Sulfate (1000mg), Marine Magnesium with 72 trace minerals (1000mg), Hydrolysate Collagen type II (500mg), MSM (250mg), Alpha Lipoic Acid (150mg) and White Willow Bark (125mg).
- Company: Instaflex
- Starting Price: $57
Instaflex Advanced is a doctor-formulated (by Chief Medical Advisor, Dr. David Katz) dietary supplement proposed to provide relief and improve flexibility in as quick as seven days, with benefits unraveling over long-term uses. In addition to relying on scientific backing, the expert – whose credentials were verified – ensured that the formula underwent third-party lab-testing and multiple testing, for that matter. To date, it remains a #1 seller across multiple GNC franchises six times, which gives Instaflex Advanced a competitive advantage. At this point, what else could we possibly ask for, right? Each capsule comprises of Turmeric (200mg), Resveratrol (100mg), AprèsFlex Boswellia serrata (100mg), UC-II (40mg), Hyaluronic Acid (5mg), and BioPerine (5mg).
Jocko Joint Warfare
- Company: OriginLabs
- Starting Price: $69
Jocko Joint Warfare embodies the power of natural anti-inflammatory compounds trusted to alleviate joint pain, reduce joint inflammation, and ensure protection against age and wear-related issues. Initially formulated with recovery for athletes in mind, the team at OriginLabs strongly believes that it is equally helpful for the public. Like many of the providers on our list, this company also sought insight from scientific evidence. In turn, they devised a formula that rejoices the synergy established among the likes of Glucosamine HCl (750mg), MSM (500mg), Turmeric (400mg), Sea Cucumber (150mg), Boswellia serrata (140mg), Quercetin (100mg) and Sodium Hyaluronate (20mg).
Besides Jocko Fuel, the same team is responsible for Go Energy Drink and Warrior Kid. That said, CEO and Head of Formulations for OriginLabs, Brian Littlefield, wants everyone to reflect upon the following: “As we age, we put wear and tear on our joints and what we want to do is we want to protect those and help those heal […] So, if you are in need of some joint pain relief or you’re just putting that extra wear and tear on your body, definitely check out Joint Warfare.”
- Company: LiveConscious
- Starting Price: $29.99
MovewellPlus is a supplement for anyone in dire need of a surge in mobility and flexibility. This formula has been developed to help the body direct collagen to the joints. As a company, LiveConscious promises to remain curious about finding traditionally sourced, clinically proven ingredients that balance the mind, body, and spirit. Equally important to them is being fully transparent about labeling, ingredient safety, product potency, and third-party lab testing. Together, this is certain to give every interested party peace of mind. On that note, a total of four capsules daily, as per the LiveConscious team, should do the trick, because they encompass AprèsFlex Boswellia serrata (100mg), Glucosamine Sulfate (1500mg), Chondroitin Sulfate (600mg), MSM (600mg), Turmeric (100mg) and Hyaluronic Acid (100mg).
Pain Relief Cream
- Company: MindBody Matrix
- Starting Price: $59.77
The MindBody Matrix Pain Relief Cream combines essential oils, botanical extracts, and Red Light Technology to relieve body pain and its effects on mental and physical health. This approach is trusted to help manage inflammatory response, ease stress and anxiety caused by pain, and target deep pain – all without using parabens and phthalates.
According to the MindBody Matrix team, Red Light Technology was used to imprint healing frequencies into each bottle of cream, which then gets transferred to our bodies during application. The supposed interaction between the technology used and the selected ingredients promote relaxation on a cellular level. Founded by Dr. TK Hyunh, MindBody Matrix flourished in 2012 because of his passion for helping others, rooted in him since he was ten years old. Today, MindBody Matrix stands as a bio-energetic company that uses science and integrative medicine to alleviate pain. This platform is also used to advocate for veterans! The nine main calming extracts are apropos of the ingredient list: Aloe Vera, Arnica, Boswellia, Calendula, Chamomile, Lemon Balm, Lavender, Tea Tree, and Peppermint.
Move Free Advanced
- Company: Schiff
- Starting Price: $19.79
Schiff’s Move Free Joint Health is an advanced dietary supplement that claims to support five signs of joint health, i.e., mobility, comfort, strength, flexibility, and lubrication. As a result, the team found ingredients that individuals tended to each one of them. What drew us to Schiff is their extensive line of muscular health products. For instance, should individuals also require healthy cartridges, their Move Free Ultra is the way to go. Similarly, if more emphasis were placed on omega-3s, then the Move Free Ultra Omega is worth considering.
Another facet that amazed us was their expertise. Established in 1936, the team at Schiff has always seen the need to find a balance between nature and science, which remains crucial in their formulation processes. Founded by Eugene Schiff, who immigrated to Detroit at 19 to become a pharmacist, he realized that he didn’t want to follow conventional practices. Instead, he focused on selling solutions that celebrated natural foods with health features. One of his major scientific breakthroughs was discovering that rose hips carried a stronger concentration of vitamin C than oranges. Honestly, we can keep going, but it isn’t needed here!
Ultimately, each Move Free Joint Health Advanced serving (i.e., two tablets) embodies the likes of Glucosamine Hydrochloride (1500mg), Chondroitin Sulfate (200mg), Joint Fluid or Hyaluronic Acid (3.3mg), and Uniflex or FruiteX-B Calcium Fructoborate (216mg).
Nature Heals Proflexoral
- Company: Healthy Living Association
- Starting Price: $39.99
Nature Heals Proflexoral is a dietary supplement that supposedly halts inflammation while restoring and rejuvenating joint material for smooth movement. A presentation introduced Dr. Ralph La Guardia MD as the expert to have discovered this “incredible pain breakthrough.” His trip to Japan led him to stand in support of combining western and eastern medical practices; hence the existence of Nature Heals Proflexoral.
Speaking of the Healthy Living Association, this is the company that distributes Nature Heals Proflexoral. Also deemed a trademark of Legendary Ventures, the company was allegedly “founded upon the belief that we can thrive at any age with natural remedies.” And so, the team encompassing three doctors (one of them being LaGuardia), remedy researchers, and certified nutritionists created options for wellness that were well-researched and consequently can pave the path towards “Freedom to live a happy, comfortable, pain- and disease-free life.”
Regarding ingredients, each serving (i.e., 3 capsules) contains Glucosamine Sulfate (1500mg), Boswellia serrata (200mg), Chondroitin (150mg), Turmeric (150mg), Quercetin (25mg), L-Methionine (25mg), MSM (25mg) and Bromelain (25mg).
Triple Joint Health
- Company: 3 Naturals
- Starting Price: $49
Triple Joint Health was presumably developed by 3 Naturals to soothe joint pain, boost flexibility, relieve stiffness, ease swelling, and repair cartilage. The two major root problems that this formula addresses include the decaying of cartilage with age and the damaging effect of inflammation on joint tissues. Rectifying these two factors permits individuals to see a lasting difference in their joints’ mobility, flexibility, and overall health. Regarding the ingredient list, each unknown serving delivers niacinamide, a doctor-formulated blend of Turmeric, MSM, N-Acetyl, and Boswellia serrata, Ginger, Basil, Rosemary, and BioPerine.
As much as the strategy aligns with what society knows about joint support, too many voids need filling. For instance, everything that we know about Triple Joint Health comes from a sales page, with no official website confirming 3 Naturals as an entity. Then, we have a list of ingredients that have not been stated down to the concentration per dose. Another factor that blew our minds is the supposed clinical evidence available, with no access to the results, but merely a graph and picture of a man in a doctor’s coat (not even a name is available). So, would we invest $49 in a product dubbed “Best Selling Formula for Joint Relief 2020” that lacks transparency all around? It is doubtful that we would.
Ultra Joint Relief Pro
- Company: NSP Nutrition
- Starting Price: $30
Ultra Joint Relief Pro was designed for men who lift. In the opinion of NSP Nutrition, this dietary supplement has the potential to reduce the risk of osteoarthritis, can defeat the effects of aging, and may safely build and sculpt one’s figure with time. The strategy behind Ultra Joint Relief Pro involves age and wear, both of which, as we already know by now, can do quite a number on our connective tissues (and thus, our joints).
That said, NSP Nutrition is no ordinary company, as the brand has been a go-to for pro bodybuilders, world-class athletes, and fitness enthusiasts since 1972. Founded by the Golden Era bodybuilder Vince Gironda, the team insists they are “committed to producing the ORIGINAL formulations used by Golden Era greats […] for Golden Era results.” This means that everything they offer is naturally sourced products that reflect science-backed ingredients, “no cutting corners – ever.”
To ensure joint mobility and flexibility, healthy cartilage, and reduced inflammation, among others, NSP Nutrition developed Ultra Joint Relief Pro. In fact, to make the latter goals possible, each serving (i.e., 3 capsules) contains Glucosamine Sulfate (1500mg), Boswellia serrata (200mg), Chondroitin Sulfate (150mg), Turmeric (150mg), Quercetin (25mg), Methionine (25mg), MSM (25mg) and Bromelain (25mg).
Joint Pain Hack
- Company: Nutrition Hacks
- Starting Price: $50
Joint Pain Hack is an all-natural supplement trusted to reduce inflammation, soothe sores and aches, restore worn-out joints and improve flexibility and mobility. Deemed a doctor-recommended formula, individuals can forestall the combined effects of clinically proven ingredients vital for immediate and long-term pain relief. The Nutrition Hacks team insists that results are felt anywhere between the first three weeks. How might this be possible? Each serving (i.e., two tablets) represents a considerable amount of Glucosamine Sulfate (1000mg), MSM (500mg), Chondroitin (225mg), Curcumin (200mg), Boswellia serrata (150mg), Bromelain (80 GDU), Turmeric Root (25mg) and Hyaluronic Acid (5mg). Though everything checks in with market standards and joint health, we would have liked to see more about the Nutrition Hacks company, which entails very scarce information.
Joint Support +
- Company: Nuzena
- Starting Price: $35
The Joint Support + is formulated by health professionals and allegedly contains scientifically researched ingredients essential for healthy joints, bones, and cartilage. Together, one can anticipate increased flexibility and mobility, freedom of movement. What allured us regarding the Nuzena team is their commitment to educating consumers on their products. Literally, with every supplement, individuals will find a summary of discoveries by the scientific community, along with the extent to which such ingredients are likely to promote wellness.
Equivalently, the Nuzena team has committed themselves to quality and transparency. To prove this, they have since created their quality certification tracker that provides real-time reports on ingredients’ quality testing results. Most of all, these reports can be easily downloaded straight from the official website. Finally, a 3-minute, 13-questions survey is in place to help consumers decipher the exact solution they need based on a series of health areas. With everything in mind, each Joint Support + serving is said to contain Glucosamine Sulfate (1500mg), Boswellia serrata (200mg), Chondroitin (150mg), Turmeric (150mg), Quercetin (25mg), Methionine (25mg), MSM (25mg), and Bromelain (25mg).
- Company: Onnit
- Starting Price: $32.95
According to Onnit, their take on the Joint Oil could go as far as repairing the body’s normal processes, which in turn is what elicits joint health benefits. Onnit is often sought for because they have always been committed to the highest quality and efficacy standards. Informed-Sport has since recognized such efforts, i.e., a third-party testing program regarded as the global gold standard for banned substances in nutritional products. If that isn’t enough, Onnit vouches to “help you be the most fully-developed person you can be.” How do they plan to do so in terms of joint health? It appears that each serving taken orally ensures that the body is equipped with the likes of Fish Oil (1600mg), EPA (160mg), DHA (130mg), Borage Seed Oil (1100mg), Gamma-Linolenic Acid (160mg), AvoVida (300mg) and Turmeric (100mg).
Move Joint Health Formula
- Company: Oweli
- Starting Price: $29.99
The Oweli Move Joint Health is a premium formula specializing in joints lubrication, flexibility, comfort, mobility, and protection. In so doing, the makers of this formula argue that joint health can be maintained, all while providing everyone with the “freedom of seamless movement.” On that note, the Oweli brand embodies wellness down to the “body’s complex interrelated structures.” In other words, temporary relief is not enough for this team, as they aim to seek and rectify issues from deep within.
The ingredient list is comparable to many of the providers that qualified for our top picks of 2021. All it takes to see and feel desirable results is a serving of three capsules encompassing Glucosamine Sulfate (1500mg), Boswellia Extract (200mg), Chondroitin (150mg), Turmeric (150mg), Quercetin (25mg), Methionine (25mg), MSM (25mg) and Bromelain (25mg).
Joint Relief 911
- Company: PhytAge Labs
- Starting Price: $69.95
Of all the supplements that made it here, Joint Relief 911 is different because it delivers one of the most simplistic formulas we’ve seen yet. The team at PhytAge Laboratories views their strategy as one that takes a “quantum leap beyond Glucosamine and Chondroitin,” adding that each serving contains “the latest, most advanced nutrients for everyday joint discomfort, pain, and stiffness.” By merely relying on anti-inflammatory, antioxidant, and moisturizing effects, the general belief is that Joint Relief 911 can refuel the body with synovial fluid at a cellular level.
As for PhytAge Labs, this company claims to spend a significant amount of time on research and development before launching their products, not to forget the expertise of their physicians. What initially started to offer digestive support quickly expanded to a brand encompassing everything from vision and fitness to beauty and, now, joints. So, without any further delay, each serving (i.e., two capsules) includes Andrographis Paniculata (250mg) and Hyaluronic Acid (30mg).
- Company: VitaBalance
- Starting Price: $29.95
ProJoint Plus has been formulated to naturally enhance the extracellular matrices found within our very skins, cartilage, ligaments, bones, and tendons. This deep-rooted approach to healing is what, as per the VitaBalance team, ensures sustained joint health. Be that as it may, VitaBalance is a company that has several brands under its belt, one of them being VitaPost (and thus, ProJoint Plus).
Referred to as a “leading natural healthy company servicing the North American market,” VitaBalance takes pride in its brands. They reflect rigorous standards, innovative solutions, and the use of ethically sourced ingredients that not only reflect company values but consumer health and trust. Speaking of tending to consumers, ProJoint Plus delivers a known combination of Glucosamine Sulfate (1500mg), Boswellia serrata (200mg), Chondroitin (150mg), Turmeric (150mg), Quercetin (25mg), Methionine (25mg), MSM (25 mg) and Bromelain (25mg).
- Company: Prosper Wellness
- Starting Price: $79.97
Another product that touts the use of CBD is the JointRestore Gummies. Prosper Wellness claims to have tackled joints health by considering the damaging effects of inflammation. By limiting its presence, healing processes can commence. The team also delivered each serving in gummies to facilitate consistency, making this more enjoyable than a chore. On that note, each gummy encompasses Boswellia serrata (200mg) and Full Spectrum CBD (20mg). For those who are unversed in CBD, full-spectrum is reckoned to elicit the entourage effect. This means that a combination of cannabinoids is delivered per serving for maximum healing instead of pure CBD. For more on the exact breakdown of cannabinoids, the required certificate of analysis has been posted on the official website.
- Company: PureHealth Research
- Starting Price: $44.10
Another joint health-focused supplement comes from PureHealth Research, which insists that their formula supplies nutrients targeting joints and cartilage to ease soreness and swelling. This company brings together skilled experts and like-minded individuals who assist in achieving the goal of helping “people reclaim the control of their own health.” How? Their time is typically allocated to reviewing scientific journals while creating evidence-based educational material to increase awareness. Each capsule includes Calcium (75mg), NEM Eggshell Membrane (500mg), AprèsFlex (100mg), and an 80mg-proprietary blend of Turmeric, Ginger, Type II Chicken Collagen, and Black Pepper.
Joint Guard 360
- Company: Thrive Health Labs
- Starting Price: $69
Joint Guard 360 is an advanced joint health formula that helps ease symptoms linked to joint pain, may elicit antioxidants content in the body, and likely enhance sharper mental performance. As maintained by the Thrive Health Labs team, this company was founded to achieve wellness, which starts by providing nutrients on a cellular level. Before that, the team allegedly stressed the importance of five guiding principles, such as producing their solutions in the U.S., ensuring third-party lab-testing, choosing top quality, science-backed ingredients, and providing consumers support as needed. How have these values been echoed in Joint Guard 360? By the looks of it, each serving contains Turmeric (800mg), Glucosamine Sulfate (200mg), Curcumin (100mg), Ginger Extract (100mg), Chondroitin Sulfate (50mg), Boswellia Extract (40mg), MSM (10mg), BioPerine (10mg), Quercetin (8mg), Methionine (8mg), and Bromelain (8mg).
Golden Revive +
- Company: UpWellness
- Starting Price: $57
Formulated by Dr. Joshua Levitt, Golden Revive + is deemed a fitting solution for people struggling with stiff joints, ligaments, tendons, and muscles. In some ways, we saw similar qualities to that of Thrive Health Labs, as both companies’ methodologies go beyond serving joint health. With Golden Revive +, people get a blood circulation enhancer and a cholesterol and blood sugar regulator. Then again, most of our picks are comparable and may equally serve different roles depending on the ingredients found per serving. While on the subject of servings, each one (i.e., two capsules) considers a healthy amount of Vitamin C (6mg), Magnesium (67mg), Boswellia serrata (333mg), BCM-95 Curcumin (333mg), Bromelain (167mg), Natural Quercetin (190mg) and Piperine (7mg).
Finally, in researching UpWellness, one thing stood out about them, and it involves their definition of nutrients. The term “nutrients” is often linked to food, but to the UpWellness team, it also encompasses every actionable measure. Whether it be physical activity, habits, or food, anything and everything that influences one’s health for the better is viewed as nutrients. Aside from that, naturopaths’ apparent involvement has a say in what goes in each formula! This is sure to convince consumers who are typically doubtful of supplements ingestion.
Glucosamine Chondroitin Turmeric & MSM
- Company: Vimerson Health
- Starting Price: $26.87
As hinted in the title, “Glucosamine Chondroitin Turmeric & MSM,” Vimerson Health’s take on joints health involves four key ingredients (along with others) that are trusted to balance inflammation, provide support, and neutralize the harmful effects of free radicals. In this sense, health as a whole may be accounted for, which is more sensical than having a supplement for every conceivable health condition.
Like most companies, Vimerson Health entered this industry to help people journey to a healthy lifestyle. Thus, the best way they know how to help is by providing “natural, safe, and effective dietary supplements that complement exercise and nutrition efforts.” Known for their versatility, scientific reliance, and commitment to guiding consumers, Vimerson Health could be worth considering. While they aren’t unique, barely meeting the basic requirements for a joints supplement suffices.
Getting back to the supplement’s fact, it suggests three capsules daily comprised of Glucosamine Sulfate (1500mg), Boswellia Extract (200mg), Chondroitin (150mg), Turmeric (150mg), Quercetin (25mg), L-Methionine (25mg), MSM (25mg), and Bromelain.
- Company: Zenith Labs
- Starting Price: $49
Moving forward on our list, we have Joint N-11, which is said to deliver pure niacinamide critical for joint tissue health. In addition, supporting ingredients have been considered to attain flexibility and mobility while also gradually freeing the joints of discomfort. Medical Research Director of Zenith Labs, Dr. Ryan Shelton, appears to be the face of this brand, seeing that his expertise in bridging the gap between traditional and modern medicines is what led to Joint N-11 and many other products to date. The expert advocates for clinically proven, natural ingredients and runs his medical practice in Hawaii. How can anyone neglect Zenith Labs’ partnership with Vitamin Angels to help children in need?
In keeping with everything mentioned so far, each Joint N-11 serving (i.e., two capsules) equips the body with Niacin (100mg), Ginger Root (200mg), Methylsulfonylmethane (200mg), N-Acetyl L-cysteine (100mg), Boswellia (100mg), Rosemary (100mg) and a Soy Lecithin and BioPerine blend (50mg).
- Company: Zenith Labs
- Starting Price: $49
Another equally worthy joints support introduced by Zenith Labs is their Longevity Activator. The approach taken here is somewhat relatable in terms of the supporting ingredients and promoting healthy aging deep within our cells. Still, in general, the goal appears to implicate the need to eliminate inflammation and boost antioxidants content. Hence, Dr. Ryan Shelton considered the likes of Green Tea (100mg), Taurine (100mg), Chebulic Myrobalan Fruit (50mg), Astragalus Root (50mg), Berberine (25mg), Purslane (25mg), Desert Broomrape (25mg), Cordyceps (25mg), Ashwagandha (25mg), Asian Ginseng (25mg), Turmeric (25mg), Resveratrol from Japanese Knotweed (25mg), Pterostilbene (25mg), Fisetin (25mg), L-Carnosine and a 25mg-Absorption Support Blend.
- Company: 1MD Nutrition
- Starting Price: $49.99
Last but not least, we have 1MD Nutrition’s MoveMD, a formula that is touted to offer only clinically studied ingredients for a comprehensive joint health solution. By gathering antioxidants, advanced collagens, and hyaluronic acid, the 1MD Nutrition team affirms a reduction in joint discomfort in as few as five days, improved connective tissues, mobility, flexibility, and most importantly, restricting the effects of oxidative stress on the entire body are all feasible.
Besides relying on clinical studies, 1MD Nutrition is known for being truthful about its manufacturing processes and ensuring nothing but scientifically proven ingredients are delivered per serving at respected doses. Furthermore, this team has a series of health resources that guide consumers towards making healthy decisions, which is always a plus.
Of course, for a brand to have “MD” behind it may imply some form of participation of doctors. And as per our guest, there are a total of five such physicians on the team! Together, they seem to have arrived at a consensus regarding the ingestion of AprèsFlex Boswellia (100mg), Zanthin (2mg), Types I, V & X Eggshell Membrane Collagen (100mg), Type II Chicken Sternum Collagen (280mg) and Hyaluronic Acid (25mg).
The Classification System that Approved Our Top 32 Picks
By now, one thing should be sure, though several joint supplements exist (and to some degrees are comparable), unique thought processes have been reflected. Our editorial team was generally happy with the results because diversity in strategies often yields a complete picture of how joint health can be improved. But before studying the ingredients, we want to take some time to go over the different facets of our classification system. Bear in mind that this system reflects our expectations, and in no way are they set in stone. Ultimately, we prefer to swear by it, but it is entirely up to individuals to either alter or build on top of the following:
Company Background & Transparency
We were captivated in many instances, mainly with ingredients, but hardly anything was disclosed concerning the company/ makers. How should one proceed in a case like this? Our editorial team believes it’s ideal for watching the product because the lack thereof is a concern. Having such information gives consumers a sense of the processes, the testings, the suppliers, and many others. Transparency as a factor plays nicely into this scenario. Companies are usually open about everything because transparency builds trust. Likewise, transparency also implies taking responsibility when things are unclear or go haywire. Without knowledge of the company, transparency drops significantly, and this leaves the product with red flags.
Clinically Proven Ingredients and Doses
All-natural ingredients have been garnering a lot of attention for some time now. A whole body of evidence suggests that including alternative medicine with conventional treatments can alleviate certain conditions. However, this does not apply to all plants and herbs. A common facet among our top picks is the use of natural ingredients. When we assessed the supplement’s fact for each, we wanted to ensure that the formula embodied clinically proven ingredients at appropriate doses.
The former indicates whether a chosen ingredient fits a health condition, while the latter indicates efficacy. Extra emphasis should be placed on dosing because anything outside of a tested range could be meaningless. Also, individuals must review the demographics of a study because something that works for, say, early adults only may not be as helpful for the elderlies. Therefore, the sample of participants should be as random as possible to generalize an entire population potentially.
Up next, we have supporting ingredients. Undoubtedly, each of the listed supplements includes elements that are trusted to promote healthy joints synergistically. To what extent does synergy hold? There must be a reason why two or more ingredients are believed to work together. In an ideal setting, science would determine whether such a combination is valid or not; however, this is rarely the case. Most often, supplements providers bring together such ingredients because each one is known for targeting joint health. Nevertheless, it is always a good idea to research the combined effects along with the individual ones.
Reliability of Claims
Reliability of claims is an umbrella term for us, as it encompasses advertised benefits, the processes, titles earned, and whether a solution has been doctor-formulated. For a company to insist on relief in a few days, they need to provide strong evidence. Failing to do so puts them at the bottom of the list. Similarly, if a supplement is touted as the best in America, multiple sources should suggest this. One that gets us all laughing is “doctor-formulated,” especially when the health practitioner’s credentials cannot be verified. Fortunately, the claims we’ve run into were supported, with hardly any hiccups along the way.
When reviewing a supplement, we don’t simply rest at the company, transparency, ingredients, science, and claims made. Given the level of saturation found in this specific category of supplements, we need plenty of properties that permit us to arrive at the top 32 out of thousands. To us, this comprises anything unique to the company. Some examples include third-party lab testing and results, additional guides and resources that facilitate healing, money-back guarantees, actions that give back to the community, bundle deals, complete availability of customer service teams, etc.
Value for Price
Last but not least, we have value for the price, which is rarely considered. But wait, doesn’t everyone study the price before investing? The short answer is yes, but the long answer is maybe. “Price” and “Value for Price” are two different concepts. The former suggests a number given to a product, whereas the latter reflects whether the number is meaningful.
Unfortunately, consumers tend to make decisions merely based on the number and fall short on assessing a product’s features and whether the number is truthful. In other words, why pay large sums of money for a solution that purely contains natural ingredients when a competitor’s product is priced similarly but also checks off accompanying features, reliability of claims, and supporting elements on our classification system?
Have We Reached an Equilibrium Between Tradition & Science?
The FDA does not approve dietary supplements; therefore, individuals need to be careful when selecting their products. One way to gain confidence in joint health supplements is by examining the viewpoints of the scientific community. Is there enough evidence suggesting a highly probable chance of healing by ingesting plants, herbs, or any ingredient for that matter? This is a question that should be scrambling in one’s mind. Our editorial team decided to investigate the top five recurring elements found throughout this guide to get the ball rolling. In reality, each one should be evaluated, and we’ll leave that task to interested parties. Nevertheless, below is a summary of what the scientific community has to share:
Glucosamine sulfate is a natural sugar found within and surrounding our fluid and cartilage that helps cushion joints. According to a 2011 review, the likes of glucosamine sulfate, chondroitin sulfate, hyaluronic acid, collagen hydrolysate, the inclusion of antioxidants and omega-3 fatty acids can effectively reduce osteoarthritis symptoms. Specifically, such ingredients are believed to house chondroprotective properties, implying that the essential components of cartilage and synovial fluids are stimulated. Regarding their anti-inflammatory properties, these are what helps to “slow the progression of cartilage destruction and may help to regenerate the joint structure .”
Another source that reviewed the scientific relationship between glucosamine sulfate and joint health summarized that its ingestion could treat osteoarthritis, rheumatoid arthritis, and osteoporosis symptoms. Moreover, there is a consensus that this molecule could be effective as a long-term treatment by reducing pain, maintaining joint space, and prolonging disease progression. As encouraging as these results are, it could be interesting to see how glucosamine sulfate performs under the presence of multiple other joint disorders .
Widely known as the Indian frankincense, this plant belongs to the Burseraceae family and is native to most of India, Punjab, and some regions in Pakistan. In searching for answers, we stumbled upon a 2020 meta-analysis of randomized controlled trials that involved Boswellia versus western medicine in patients with osteoarthritis. From seven trials encompassing 545 patients, the researchers reported that groups taking Boswellia experienced pain relief, reduced stiffness, and improved joint function, among other markers.
In other words, the “current evidence [suggests that] Boswellia and its extract may be an effective and safe treatment option for patient with OA, and the recommended duration of treatment […] is at least 4 weeks .” A 2014 study investigating the antioxidant and anti-arthritic activities of Boswellia serrata gum resin extract (BSE) in collagen-induced arthritis in Wistar rats discovered desirable results. After administering doses of 100 and 200mg/kg once daily for 21 days, the researchers found that BSE significantly changed the studied parameters.
Oral administration was found to reduce levels of inflammatory mediators significantly. By the end, the team highlighted that “the abilities to inhibit proinflammatory cytokines and modulation of antioxidant suggest that the protective effect of Boswellia serrata on arthritis in rats might be mediated via the modulation of immune system .”
Chondroitin sulfate is a chemical attached to proteins within the human and animal cartilage. Usually, it is orally taken with glucosamine or other ingredients known to treat osteoarthritis, which explains a lot. More on consumption, chondroitin is safe for up to six years of use with mild stomach pain and nausea . Nevertheless, a 2010 review that looked at the mechanisms of chondroitin sulfate and its effects had some interesting arguments to make.
First, its efficacy is possibly due to its ability to stimulate the production of proteoglycans (i.e., essential components of the extracellular matrices) while decreasing the breakdown of chondrocytes (i.e., responsible for cartilage formation). Second, it has the potential to exert anti-inflammatory activity. To wrap things up, the researchers emphasized that the positive effects of chondroitin might stem from a “proper balance between anabolism/catabolism in the articular tissues .”
MSM is described as a “non-pharmacologic nutrition supplement” used as a treatment for osteoarthritis. A team of researchers was on a mission to outline the effect of MSM on osteoarthritic joints and mobility. One hundred patients with hip or knee osteoarthritis were either stratified into a control or placebo group, where the former was administered 6g of MSM. After 26 weeks, the MSM group presented significant decreases in all subscales with improved performance of daily activities.
This led the team to affirm that “MSM improved all physical symptoms in the Western Ontario and McMaster University Osteoarthritis Index visual analogue (WOMAC) scale during the short intervention without any adverse events .” Another source summarized a study of 100 people over 50 years of age who were administered 1.2g of MSM for 12 weeks.
By the end of this period, the researchers confirmed decreased pain, stiffness, and swelling of joints compared to the placebo group, not to forget the improved quality of life and alleviation in walking and getting out of bed. This same source also referenced a study that looked at the combined effects of glucosamine and MSM to find that the duo reduced lumbar stiffness and pain and increased quality of life .
UC-II Standardized Chicken Cartilage
UC-II stands for undenatured type II collagen derived from chicken sternum cartilage. A 2015 study evaluated the efficacy and tolerability of UC-II for knee osteoarthritis pain while comparing the results to the placebo and glucosamine hydrochloride plus chondroitin sulfate groups. In this case, 191 volunteers were split into the three groups above, each receiving a dose of 40mg, a placebo, and 1500mg plus 1200mg, respectively.
By the 180th day, the UC-II group allegedly demonstrated a significant reduction in overall WOMAC scores compared to the latter two groups, adding that its supplementation was well tolerated . Another study that only looked at the efficacy of UC-II over 120 days at a dose of 40mg arrived at a similar conclusion. Mainly, the researchers found that 1) 40mg was well-tolerated, 2) it led to improved knee joint extension in healthy subjects, and 3) it could prolong pain-free results while alleviating joint pain from occasional activities .
From our initial research, we were able to show that scientific evidence on the top five recurring ingredients does exist, and they are mostly in favor of them. Matter-of-factly, some studies have also considered more than one ingredient together, which is uplifting, as all the top joint health supplements of 2021 include a mixture of ingredients. Moving forward, everyone should conduct similar research on their product of choice before placing an order.
Frequently Asked Questions About Joints Supplements
Q: What is a joint?
A: A joint is a place at which two or more bones meet. They can either be inelastic (i.e., those found in our skulls) or flexible (i.e., located in the knees, hips, and shoulders) .
Q: What does joint pain feel like?
A: The severity of joint pain will vary from one person to the next. However, it can range anywhere from a burning and sharp sensation to grating pain .
Q: What foods might cause joint pain?
A: Sugars, trans and saturated fats, refined carbohydrates, MSG, and alcohol are foods and drinks that should be avoided for healthy joints .
Q: Is it possible to experience pain in multiple joints?
A: Yes, this could be a consequence of injuries, fractures, overuse of joints, stress and anxiety, autoimmune diseases, and different types of arthritis .
Q: What is cartilage, and why is it important?
A: Joints have cartilage (i.e., hard slippery tissues) on the ends of the bones to provide cushioning. The healthier one’s cartilage content, the healthier one’s movement, which means bones will glide over one another rather than experiencing friction.
Q: What are some of the most common types of joint conditions/disorders?
A: According to the National Institute of Arthritis and Musculoskeletal and Skin Diseases , the most common types of joint conditions/disorders include:
- Arthritis: A disorder affecting the joints
- Fibromyalgia: A condition that exhausts tender points in the body
- Gout: A form of arthritis because of uric acid (i.e., a waste product) buildup in the joints
- Lupus: An autoimmune disease that causes joint and muscle pain, among others
- Osteoarthritis: arthritis experienced mainly by the elderlies
- Rheumatoid arthritis: An autoimmune disease that forces the immune system to attach the joints
- Juvenile arthritis: Arthritis in children
- Tendonitis: Inflammation in the connective tissue that connects muscles and bones
- Pseudogout: Arthritis in the knees, hips, wrists, and hand joints
Q: What lifestyle choices can be improved for healthy joints?
A: Physical activity is essential as it strengthens muscles around the joints while ensuring that they function as required. Regardless of whether one has arthritis or not, physical activity of some form is always recommended (even arthritis-friendly ones). In such cases, wearing protective padding prevents injuries. As important as physical activity is, so are stretching and warming up. Finally, individuals should consider a balanced diet with fruits, vegetables, whole grains, lean proteins, and dairy products.
Q: What supplements can be taken to promote joint relief?
A: Our top contenders for joint relief are a great start, seeing that glucosamine, chondroitin, UC-II, MSM, and many other related ingredients are trusted to enhance joint health altogether.
Q: What is the impact of aging on joints?
A: As we age, our cartilage degrades, which gives rise to stiffness, whether it be after sitting or standing for long hours. Unfortunately, aging also introduces wear, which prevents the joints from keeping up with daily demands.
Q: Are all joint supplements made equally?
A: Based on our analysis, not all joint supplements are made equally. Therefore, it is always good practice to research each one before finalizing a supplement. It is important to note that joint supplements can be a hit or miss, as the level of relief depends on one’s medical history, lifestyle choices, medication intake, and physical activity, to name a few.
Q: Are people with arthritis at more risk of experiencing complications from the flu?
A: Yes, according to the CDC, people with rheumatoid arthritis or lupus are more likely to develop complications from the flu than most people. Such complications may include sinus, ear infections, bronchitis, and pneumonia .
Q: What type of professionals can help with joints pain?
A: Depending on the type of pain experienced, individuals may refer to a physical therapist, occupational therapist, orthopedists, physiatrists, or rheumatologists. But first, talking to the primary care provider is best, as they are likely to direct individuals toward the right path.
Q: How is arthritis diagnosed?
A: Usually, doctors diagnose arthritis by considering a patient’s medical history, physical examination, X-rays, and blood tests .
Q: Is it possible to have more than one type of arthritis at once?
A: Yes, it is possible to be diagnosed with more than one type of arthritis at once. Should individuals fear the endless possibilities, it is always a good idea to bring up any early signs or symptoms to a health professional.
Q: Does obesity make it challenging to maintain joints health?
A: Yes, being overweight adds extra weight on the knees to carry. Likewise, being underweight is problematic, as it implies the lack of muscle to keep joints strong and stable. Hence, simple activities such as bicycling, pilates, swimming, walking, and yoga can be helpful .
The Top 32 Performing Joints Supplements in 2021 Final Verdict
Ultimately, issues in the joint can create a devastating domino effect leading to poor health and deprivation of independence. As imperative as maintaining physical activities, eating balanced diets, and limiting unhealthy lifestyle choices, having additional support in dietary supplements can make pain management somewhat smoother. This is not to say that they are cures or treatments for a diagnosis, but instead, they can help with overall alleviation.
Based on our analysis guided by the specially made classification system and scientific evidence, most of the top 32 supplements that qualify carry substances essential for recovery, maintenance, and improvement in joints. However, a few players either exaggerated the benefits, weren’t transparent, or introduced a supposed doctor/researcher with unverifiable credentials. These are examples of solutions that should be unmasked (as we did in this guide) and discarded altogether.
The first best actionable step one could take regarding joints pain is seeking a professional’s help. They can decipher the exact source of pain, how much of an issue it might be, and future steps to reflect upon. Once confirmed, individuals may want to refer to our top list to see if any supplements can be taken for extra support. In identifying a couple, we ask that everyone researches each one thoroughly before concluding about one.
Following everything discussed to this very point, we hope that this guide provides sufficient knowledge on how to differentiate the good from the bad, and ultimately, relying on unique means of living a pain-free and happy life. Until our next update, we are optimistic that everyone will take joint health seriously and make appropriate decisions accordingly!
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Please understand that any advice or guidelines revealed here are not even remotely a substitute for sound medical advice from a licensed healthcare provider. Make sure to consult with a professional physician before making any purchasing decision if you use medications or have concerns following the review details shared above. Individual results may vary as the statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease.