Do I exist? Do you exist? How do I know you exist?
These ancient questions have been given new urgency by 21st century science. Some of San Diego’s top researchers met recently in La Jolla to discuss them.
The topic was “mini-brains” — pea-sized structures of human neurons grown from stem cells. Called “human brain organoids” by scientists, they are yielding important discoveries about autism, brain damage from Zika and other neurological conditions.
These mini-brains enable scientists to probe brain functioning in a way that’s not ethical in healthy humans. said Dr. Alysson Muotri, a UC-San Diego brain organoid researcher and a meeting leader.
But the mini-brains are becoming more complicated, giving rise to the theoretical possibility they might eventually acquire minds of their own, he said.
These mini-brains show no signs of consciousness at present, he said, and existing technological limitations make that very unlikely.
Muotri said mini-brains are limited in size because they don’t develop blood vessels. That means as the organoids grow in their cultures, the inner ones begin to die. They also don’t develop all the types of cells found in a human brain.
But Muotri and colleagues recently demonstrated that these organoids can make brain waves similar to those of premature babies — something never done before. And as for the future, it’s impossible to say.
Patricia Churchland is a Salk Institute professor emerita who studies the linkage between philosophy and neuroscience. She said the possibility that human brain organoids could eventually become self-aware should be considered.
To avoid speculation, she said discussions need to be grounded in what science has already discovered about consciousness.
If scientists don’t discuss these issues with the public, they’ll become vulnerable to political activists who exploit a lack of knowledge, Churchland said.
“Those highfalutin scientists who have the moral arrogance to play God are a favorite target,” she said. “And you do not want to be that target.”
The public’s confidence in science could be lost in that confrontation, she said. And that would undermine efforts of scientists and doctors to develop better ways to treat and prevent diseases.